Mirroring SATA to USB: possible - yes. Making sense - no idea. I have stopped using USB for TrueNAS years ago. Simply too unreliable.
As for the board: 2 SuperDOM ports for SATA-DOMs, 4 additional SATA ports for regular disks/SSDs. Or 6 regular disks and no DOMs. The ports are just regular SATA with additional power for DOMs.
Depending on what you want to build ... I would consider:
- 2 SATA DOMs for booting
- 4 spinning disks
1 or 2 AOC-SLG3-2M PCIe card(s) for 2 or 4 additional SSDs
Nice home or SMB system.
Edit: quickly checked the board manual. Looks like the PCIe slots do nut support bifurcation. You can still use
one PCIe/NVMe SSD per slot but not two.