I run 6 WD Reds 4TB (I want an extra 2, but I need space elsewhere to rebuild the pool). My case is a Fractal R5 non-windowed. It was built to be silent and without the disks you cannot hear the box, even at full tilt CPU wise it’s still silent. With the disks it’s still quiet but I hear the disks rotating (probably pitch or vibration), maybe a different case would be better, but it’s just the trade-off with the bays. Either way, it’s good enough at sub 20db from a crappy phone app (I need to find my meter to test this properly, so take that with a pinch of salt). I myself am sensitive to pitch, I hear coil wine more than most people and I'd like to further improve things by making it properly silent like it is without the disks spinning.
On the life span front, I’m still interested in opinions, but I feel the general census is keep them spinning to reduce the wear on spin-ups. I think I might optimize spin down for testing and see how much down-time there is. I could see 24 hours at times between snapshots and usage, but who knows until I test it in that configuration with proper monitoring. I think in situations like that there could be less wear on the disks, but like I say I see no studies on the matter.
Thanks,