1) Should be completely safe. However, you will not be able to UNDO it, so typically those of us who do lots of ZFS will wait to upgrade, a month, a year, or, my favorite, right BEFORE upgrading to a new version of FreeNAS/TrueNAS. This counterintuitive strategy guarantees that you're introducing new feature flags and aren't stuck on a pool version from ten years ago, but also guarantees that you can roll back from your about-to-be-installed version to the version currently running.
2) Shouldn't be.
3) No.
4) Perhaps a second. Maybe two.